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Physiological glycation by methylglyoxal and prevention by glyoxalase 1 will be presented by Pr. Thornalley

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Professor Paul J. Thornalley from the University of Warwick, the United Kingdom, will give a talk about Physiological glycation by methylglyoxal and prevention by glyoxalase 1 - involvement in disease mechanisms and development of glyoxalase 1 inducer therapeutics, at the Paris Redox World Congress 2016.


According to Pr. Thornalley, methylglyoxal (MG) is a dicarbonyl metabolite and precursor of major quantitative advanced glycation endproducts (AGEs) of protein and DNA, hydroimidazolone MG-H1 and imidazopurinone MGdG, respectively. Glyoxalase 1 (Glo1) of the cytoplasmic glyoxalase pathway provides the major route for metabolism of MG and enzymatic deference against MG glycation. Accumulation of MG - “dicarbonyl stress” - occurs in ageing and metabolic and vascular disease. Dicarbonyl stress is a driver for insulin resistance and inflammation of obesity, vascular complications in diabetes and renal failure, and cardiovascular disease. Small molecule inducers of Glo1 expression are in clinical evaluation for therapeutic agents to counter dicarbonyl stress-linked disorders.

 

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