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Compte Rendu_3D_aoxISANH Antioxidants 2014 was a huge success and gather a record of participation for the 14th edition with more than 63 oral presentations and 153 posters which were presented during the meeting.

The participants were coming from clinical, pharmaceutical, cosmetics and all oxidative stress related fields.

If you cannot attend this international meeting, you can order the abstracts book by clicking here.

 

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Dr Nikiforov was awarded for his researches about Reactive oxygen species (ROS) and aactivation of NF-E2- related transcription factor 2 (Nrf2), a key transcriptional regulator driving antioxidant gene expression and protection from oxidant injury.


On his study, Dr Nikiforov reports that in response to elevation of intracellular ROS above a critical threshold, Nrf2 stimulates expression of transcription Kruppel-like factor 9 (Klf9), resulting in further Klf9-dependent increases in ROS and subsequent cell death. His team demonstrated that Klf9 independently causes increased ROS levels in various types of cultured cells and in mouse tissues and is required for pathogenesis of bleomycin-induced pulmonary fibrosis in mice. Mechanistically, Klf9 binds to the promoters and alters the expression of several genes involved in the metabolism of ROS, including suppression of thioredoxin reductase 2, an enzyme participating in ROS clearance. Their data reveal an Nrf2-dependent feedforward regulation of ROS and identify Klf9 as a ubiquitous regulator of oxidative stress and lung injury.


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awardPedroIt is an honor to announce the award discerned by ISANH to Dr Pedro Buc Calderon, Université Catholique de Louvain, Belgium for his scientific contribution during ISANH Antioxidants World Congress 2014.

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parisThe Organizing Committee remind you:

  •  ISANH Antioxidant Conference will be held at Marriot Hotel Paris Rive Gauche


Marriott Hotel Paris Rive Gauche
17 Boulevard Saint Jacques
75014 Paris
Metro Line 6 - Saint Jacques / Glacière

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logo2014This two-days conference will gather a record of participation for the 14th edition with more than 63 oral presentations and 153 posters which will be presented during the meeting.

 

The participants are coming from clinical, pharmaceutical, cosmetics and all oxidative stress related fields.

 

Among universities and companies attending the conference:

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ParisYou can find on the following link the list of distinguished speakers and short oral presentations accepted for ISANH Antioxidants World Congress 2014.

To access to the updated program, please click here.

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may15The Scientific Committee of ISANH Antioxidants 2014  reminds you that you have until Thursday, May 15 to send your abstract for poster presentation.

After this date, any abstract will be accepted.

For all information about abstract submission, please click here.

www.isanh.fr


BatteuxPr Frédéric Batteux, from University Paris Descartes, France published in January 2014 a paper in the Journal of Clinical Investigation on the role of an original SOD mimic, mangafodipir, on oxaliplatin-induced peripheral neuropathy. The result of this paper is original as it combines both basic research and a clinical trial and open a new therapeutic opportunity for treatment of chemotherapy induced neuropathy.

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woman-moisturizer beautiful-skin
During ISANH Antioxidants World Congress 2014, the scientific committee will allocate time to discuss about Oxidative Stress & Skin 2014: Mechanistic & Strategies.

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BoutonDuring ISANH Antioxidants World Congress 2014, Dr Cécile Bouton, from CNRS, France, will present the Maturation and role of mitoNEET in Fe-S cluster biogenesis. MitoNEET is a mitochondrial Fe-S protein of the outer mitochondrial membrane and novel target of the antidiabetes drug. Iron-sulfur (Fe-S) cluster are among the most ubiquitous and versatile metal-containing prosthetic centers in biology. Fe-S cluster-containing proteins are essential for life, by sustaining fundamental processes : photosynthesis, nitrogen fixation and oxidative respiration.

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MartinBergo

According Pr Martin Bergo, from Sweden’s University of Gothenburg, the concept that reactive oxygen species (ROS) induces DNA damage that can lead to cancer underlies the rationale for using antioxidant supplements to protect against cancer.

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leichertRedox proteomics is a powerful tool to study redox regulation and signaling. Lars Leichert will present strategies to determine the redox state of hundreds of protein thiols in a single experiment. Such a global overview of the cellular redox state can teach us a lot about the targets of reactive oxygen and nitrogen species and can uncover strategies of the cell to counteract oxidative stress. The surprising specificity of oxidants we can observe in these experiments is probably one of the bases of thiol-based redox signaling.

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VickiColvinCommon catalyst cerium oxide opens door to nanochemistry for medicine.

Pr Vicki Colvin and her team from Rice University are enhancing the natural antioxidant properties of an element found in a car’s catalytic converter to make it useful for medical applications.

Oleylamine (red dots) and oleac acid (blue) layers serve to protect a cerium oxide nanosphere that catalyzes reactive oxygen species by absorbing and turning them into less-harmful molecules. The finding could help treat injuries, guard against radiation-induced side effects of cancer therapy and protect astronauts from space radiation. (Credit: Colvin Group/Rice University).

 

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RajasekaranDuring the Antioxidants 2014 World Congress in Paris next June 2014, Dr Namakkal S. Rajasekaran from University of Utah School of Medicine, USA will proposes his work based on Targeting Reductive Stress Strategies.

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ThomasDuring Antioxidants World Congress 2014, Dr Bobby Thomas will present his recent study about Targeting Nrf2/Keap1 signaling pathway to treat Parkinson's disease.

He will also highlight the importance of Triterpenoids as a powerful class of antioxidants to treat this pathology.

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MiriaDuring the Antioxidants 2014 World Congress in Paris next June 2014, Pr. Miria Ricchetti from Pasteur Instutute, France will talk about "Altererd oxidant/antioxidant dynamics in a precocious ageing diseases"

For more information about the complete program, please visit www.isanh.fr.

TheileriaDr Souhila Medjkane and her team from Université Paris Diderot studied the effects of an intracellular parasite called Theileria that infects bovine leukocytes and turns them into invasive cancer-like cells.

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P.Gros

According Pr Pierre Gros, from Université Paul Sabatier, Toulouse, France "Electrochemistry has been recognized as a promising new way to detect and assay several biomarkers and study biological processes involved in the oxidative stress. Electrochemical sensors and biosensors as well as electrochemical techniques have been developed in the last 20 years to evaluate the global redox status of human tissues and fluids and to determine specific activity of reactive oxidant or antioxidant species.

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arbaultDr Stéphane Arbault from University Bordeaux 1, France will present his work about Electrochemical Detections of ROS and RNS to Assess Antioxidant Activities during Antioxidants 2014 World Congress in Paris next June 2014.


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devosDuring Antioxidants 2014 World Congress, Dr David Devos, from University of Lille Nord, France will give a presentation about the first clinical evidence about the neuroprotective potential of a therapeutically safe chelation treatment on early- stage Parkinson’s patients that were already stabilized for dopamine and responded significantly to treatment in both brain iron deposits and indicators of disease progression.

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BatteuxCancer cells display an overproduction of reactive oxygen species resulting from an exaggerated intrinsic oxidative stress. However, the concept of deleterious oxidants versus beneficial antioxidants has recently evolved. Indeed, molecules like natural coumarins have shown anti-oxidant or pro-oxidant properties depending on their intracellular concentration. Therefore, the team has investigated the structure-activity relationship of a variety of coumarin derivatives in terms of cytotoxicity towards human and murine carcinoma cell lines (HT29, HepG2, A549, MCF7, OVCAR and CT26).

During ISANH Antioxidants World Congress 2014, which will be held in Paris on June 12-13, Pr Frédéric Batteux, from University Paris Descartes, France will highlight the strategies and perspectives of Chalcone-Coumarin Derivatives as Potential Anti-Cancer Drugs.

If you are interested to know more about this strategic topic, come and join Antioxidants World Congress.

For more information: www.isanh.fr